Crh deficiency in mice is associated with highersusceptibility to innate immune responses and the development of associated colitis.Along these lines, we have previously reported that Crh−/− mice develop severe DSS colitis16, in contrast to the protective effects of Crh deficiency in other modelsof inflammation not dependent on innate immunity such as carrageenan43 or TNBS-induced enteritis14. The gene discussed is CRH; the disease is hyperinsulinemic hypoglycemia, familial, 4.