Kim et al. [33] revealed 0.33 % annual HBsAg seroclearance rate by 6-year-follow-up of 5409 patients (two-thirds were HBeAg positive) receiving LMV or ETV therapy, and demonstrated baseline low HBV-DNA, high ALT, HBeAg negativity, and absence of cirrhosis as predictors for HBsAg loss. This evidence concerns the gene GPT and Cirrhosis.