CASP12 and acute kidney injury: The expression of caspase-12 mRNA in group PHC was significantly lower than in groups AKI and ZnPP at 1 h and 6 h (P<0.01), while there were no significant differences between group PHC and groups AKI, ZnPP and PHC+ZnPP at 24 h (Fig 4 & Figure B to F in S1 File).