These results acquired added value, if we take into account that obesity is associated with a state of chronic or low grade systemic inflammation which increases the production of obesity-related inflammatory cytokines, such as IL-1β, IL-6, TNFα, leptin and decreases anti-inflammatory cytokine levels, such as adiponectin [71, 72]. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.