Accordingly, some ERMS cases of mutated phosphatidylinositol 3 kinase A (PIK3CA) have been reported (Chen et al., 2013; Shern et al., 2014) and 82.5% of RMS tumors have been found to display a strong activation of the pathway (Renshaw et al., 2013). Here, PIK3CA is linked to embryonal rhabdomyosarcoma.