AHR and atopic asthma: IL5, which is an important cytokine for eosinophil-induced airway inflammation and AHR, is associated with spirometric markers of disease severity in Korean children with atopic asthma [50], whereas the relationship between a locus in INTS12/GSTCD/NPNT and FEV1 has been identified in a meta-analysis of GWAS [51].