This finding was confirmed by modular analysis, in which only the specific module for IL4 and IL13 stimulated genes in MDM, to model Th2 activity, was significantly enriched in the TST transcriptome of TB-IRIS patients compared to both HIV seronegative patients with active TB, and to HIV-1 infected patients with clinically positive TSTs presenting with active TB that was not temporally associated with recent initiation of ARVs (Fig 5D and S10C Fig). This evidence concerns the gene IL4 and tuberculosis.