Here, we show for the first time that mCD40L but not sCD40L induces NORE1A expression in CD40-expressing carcinomas, a protein that has been recently identified as a Ras-binding partner and upon ectopic expression can promote cell death via Ras-dependant and -independent mechanism.12 The lack of NORE1A expression in sCD40L-treated cells was not due to inability of sCD40L to activate the CD40 receptor because the downstream signalling targets were activated, suggesting that NORE1A induction is restricted to CD40 activation by mCD40L. The gene discussed is RASSF5; the disease is carcinoma.