It has been reported that NORE1A expression in hepatocellular carcinomas modulates p21 expression via promoting wild-type but not mutant p53 nuclear localisation.9 However, in our experiment, p21 upregulation mediated by NORE1A expression (Figure 6a) appeared to be concomitant with downregulation of p53 expression in the cytoplasmic fraction, together with no evidence of increased p53 localisation in the nucleus (Figure 6c). The gene discussed is RASSF5; the disease is hepatocellular carcinoma.