Finally, as an independent means of confirming the capacity of Bim 23056 and cantharidin to inhibit FAS-dependent apoptosis in the liver, we used a second mouse model of FAS-mediated fulminant hepatitis induced by intravenous (i.v.)injection of the lectin ConA, a T-cell mitogen that rapidly induces liver injury.15 Anti-FAS siRNA was used to confirm that ConA-induced liver damage in this model is indeed FAS-mediated.16 Serum levels of alanine transaminase (ALT) released from damaged hepatocytes indicate the extent of liver damage in the ConA-induced hepatitis model. This evidence concerns the gene GPT and Fulminant hepatitis.