For example, TBPT significantly suppressed a series of genes involved in DNA double-strand break repair, including LIG4, CENPF, DNAJC2, RECQL, SMC6 and BRCA2 (≥ 2-fold; Supplementary Table S2), which are also considered vital targets for treating cancer cells without affecting normal cells.48, 49. Here, LIG4 is linked to cancer.