Next, we investigated Cdc42 expression in LPS or ADR-treated mice, which the former was well-recognized proteinuric mouse model,22, 23 the latter was a well-known experimental model of human proteinuria disease resemble to FSGS.4, 24 Immunofluorescent staining exhibited Cdc42 expression was decreased in glomerular podocyte of LPS or ADR-injected mice, comparing with vehicle control mice, respectively (Figure 2e). Here, CDC42 is linked to Proteinuria.