APOE and Tangier disease: Apolipoprotein A-1 and apoE promote a time, energy and Golgi-dependent formation of lipid complexes on the cell membrane, which are originally described as a “mushroom” shaped protrusions 10 to 200 nm in size on the plasma membrane of fibroblasts and THP-1 macrophages and no lipid accumulation was observed on the cell membrane in the fibroblasts from Tangier disease incubated with apoA-1 or apoE [11].