IDUA and Scheie syndrome: Mucopolysaccharidosis type I (MPS I), caused by a deficiency of the lysosomal enzyme α-L-iduronidase (IDUA), results in shortened lifespan, multisystemic somatic involvement, and variable neurocognitive degeneration because of accumulation of heparan sulfate (HS) and dermatan sulfate (DS) glycosaminoglycan (GAG) substrates in body tissues such as brain, soft tissues, chondrocytes, liver, and spleen [1].