TGFB1 and diabetes mellitus: Similarly, studies on renal transplant patients also suggested TCF7L2 was strongly and independently associated with posttransplant diabetes mellitus.22 Furthermore, Araoka et al23 did a systemic work, they found that advanced glycation end products (AGEs) induced TCF7L2 expression through transforming growth factor-β (TGF-β), and TGF-β could induce TCF7L2 translocation from the cytoplasm to the nucleus.