Protein S deficiency may be associated with the NRH.15 Above, an acquired protein S deficiency has been reported in 15% to 20% of patients infected with HIV.16,17 Eight observations of HIV-infected patients (included in our cohort) having histologically proven NRH18 had all protein S deficiency. The gene discussed is PROS1; the disease is hyperinsulinemic hypoglycemia, familial, 4.