TNF and amyloidosis: Furthermore, a continuous treatment with anakinra decreases serum amyloid A level and could so prevent amyloidosis.37 Anakinra would have greater effect than anti-TNFα agents.35 Nevertheless, incomplete responses to anakinra suggest the implication of others cytokines.39 Advances in pathogenesis, that is, inflammasome activation, provide the basis for the development of new therapies.