Although our preliminary subgroup analyses indicated that G-CSF-mobilized PBMNCs and bone marrow-derived stem cells exerted similar beneficial effects on the healing of the ulcers, we cannot determine the relative effects of the 2 sources of stem cells because no studies comparing the 2 approaches directly were included in our meta-analyses.34,35 Second, our meta-analysis included patients with lower extremity ulcers of different causes and severities, and whether autologous stem cell exerts similar beneficial effects in these clinical conditions needs to be further investigated. The gene discussed is CSF3; the disease is ulcer disease.