Receptor-interacting serine/threonine protein kinases 1 and 3 (RIP1/3) play vital roles in the necroptotic pathway[10–12].It has been confirmed that necroptosis is an important pathological phenomenon involved in glucocorticoid-induced osteoporosis[13].However, the role of necroptosis in osteocyte loss in OVX rats is currently unknown. Here, RIPK1 is linked to osteoporosis.