In line with this idea, Stankic et al., have demonstrated that during metastatic colonization, Id1 expression induces a MET and stem-like phenotype specifically in breast cancer whose mesenchymal state is dependent on the Id1 target Twist1. In contrast, this does not occur at the primary site, where this state is controlled by Snai1 [56]. This evidence concerns the gene TWIST1 and breast carcinoma.