CD8A and neoplasm: “Antitumor” immune cells include cytotoxic CD8+ T lymphocytes (CTLs), T helper type 1 (Th1) cells, type 1 macrophages (M1), type 1 neutrophils (N1), natural killer (NK) cells, natural killer T (NK-T) cells, eosinophils, and mature dendritic cells (DCs) [45-48], all of which are known to support the clearance of tumor cells.