The RDH10 promoter was amplified in cells transduced by AAV2.1-OTX2 when the OTX2 was used but not the anti-rabbit antibodies showing that OTX2 expressed through the use of AAV infection is binding to the RDH10 promoter. This evidence concerns the gene OTX2 and anti-neutrophil cytoplasmic antibody-associated vasculitis.