111-In-labeled and 99mTc-labeled monoclonal antibodies of E-selectin allow for detection of E-selectin positive immune cells in the inflammatory microenvironment; a comparison of the two methods in a clinical trial of 10 patients with rheumatoid arthritis demonstrated 111In-labeled and 99mTc-labeled anti-E-selectin monoclonal antibody have equivalent efficacy in the detection of active inflammation within joints, but 99mTc is a more readily available radioisotope with a preferred imaging time of four hours [16, 17, 18]. This evidence concerns the gene SELE and rheumatoid arthritis.