POMC and congenital adrenal hyperplasia: As a result, there is a compensatory increasein the secretion of adrenocorticotropic hormone(ACTH), resulting in adrenal hyperplasia.Worldwide, the incidence of CAH in newborns isapproximately 1/16,000–1/20,000, and approximately1/15,000–1/16,000 in Europe and the USA.In China, the incidence of CAH is unknown due tothe absence of a national screening program (2).