These patientsmay do better with a lower dose (i.e. 75 IUof r-FSH), but a dose of 75 IU r-FSH might notreach the FSH threshold for most of the patients.The two subjects with eight follicles ≥16 mm exhibiteda hyper-response, but did not get pregnant.They may have other infertility problems whichmay be addressed by in vitro fertilization (IVF). This evidence concerns the gene BRD2 and Infertility.