FOXO3 and metastasis: For instance, RASSF1-MST1-FOXO3 pathway is associated with BRAFV600E gene mutation [162], C-met pathway is associated with the growth, invasion, and lymph node metastasis of thyroid cancer [163, 164], and sonic hedgehog pathway is ubiquitously expressed in thyroid cancers and is associated with the development, staging, and lymph node metastasis of thyroid cancer [165].