Liu et al investigated 34 paraffin-embedding specimens of classical PTCs and 39 PTCs with tall-cell features, and they found that the positive expression rate of TSHR was significantly lower in PTCs than in the normal thyroid tissues adjacent to the cancers (χ2 = 15.70, P < 0.05) and lower in PTCs with tall-cell features than in classical PTCs (χ2 = 4.24, P < 0.05) [131]. This evidence concerns the gene TSHR and cancer.