This is in line with current guidelines which recommend that patients with severe congenital or acquired panhypopituitarism with three or more pituitary hormone deficiencies or identified genetic mutations may not require re-evaluation of their GH status; otherwise all patients with CO-GHD require biochemical re-evaluation and reconfirmation of GHD during transition before reinstituting adult GH replacement therapy [9, 12]. This evidence concerns the gene GH1 and panhypopituitarism.