Systemic inflammatory response syndrome (SIRS) in septic patients is characterized by an exacerbation of inflammation, with increased levels of pro-inflammatory cytokines (IL-6, TNF-α, IL-1β, etc.), as well as anti-inflammatory cytokines (IL-10, TGF-β, IL-1Ra) in the bloodstream25. This evidence concerns the gene IL1B and systemic inflammatory response syndrome.