As Cisplatin, Oxaliplatin, and Carboplatin are commonly used to treat various types of lung cancer, we wished to establish a Cisplatin-resistant variant of the alveolar A549 adenocarcinoma cell line to test whether development of resistance in this cell type similar to A2780 cells would involve an altered LRRC8A expression, VRAC/VSOAC activity and intracellular signaling along the p53-dependent cascade. Here, LRRC8A is linked to lung cancer.