AGXT2 and atrial fibrillation: In contrast, the associations of rs16899974 with both paroxysmal and chronic AF in LURIC, with late onset clinical AF and with earlier age of onset of cryptogenic ischemic stroke suggest a role for AGXT2 in more subclinical forms of AF characterized by a relatively low rate of progression to chronic AF; however, this hypothesis needs to be validated in a prospective setting.