Lyn was reported to increase cell proliferation in breast cancer cell lines [18], via binding to and phosphorylating epidermal growth factor receptor (EGFR) in the cytoplasm and chaperoning EGFR translocation to the nucleus, whereby Lyn acted as a transcription factor in the up-regulation of expression of Cyclin D1, inducible nitric oxide synthase (iNOS) and other pro-oncogenic factors [18]. This evidence concerns the gene CCND1 and breast cancer.