Although this negative feedback might serve to regulate lung cancer progression via GSK-3β, CK1α, as the downstream rate-determining enzyme that sequentially phosphorylates β-catenin prior to GSK3β (Hernandez et al., 2012), remains to play a significant role in NIFK regulated β-catenin degradation. The gene discussed is CSNK1A1; the disease is lung carcinoma.