TP53 and neoplasm: Loss of TP53 is one of the earliest occurring events in human GBM initiation (Maher et al., 2001; Wang et al., 2009; Ohgaki et al., 2004; Mazor et al., 2015; Johnson et al., 2014). This inevitably results in the accumulation of a plethora of secondary hits, which, after a long latency period, leads to tumor formation.