To recapitulate this chain of events in mice, we deleted Trp53 as an initial driver during neural development (using p53f/f; Nestin-Cre (p53ΔN) mice) and monitored brain tumor formation in late adult life. After 8 months, brain tumors arose in p53ΔN mice with high penetrance (Figure 1A and B), similar to previous observations using an hGFAP-Cre model (Wang et al., 2009). The gene discussed is NES; the disease is brain neoplasm.