Not all cases were tested completely, thus of assessable patients 26/37 (70 %) had signs and biochemical findings suggestive of hypercortisolism, 2/36 (6 %) findings of concomitant elevation of catecholamines (urinary noradrenaline 842 nmol/L, normal < 400, and plasma normetanephrine 1.3 nmol/L, normal <0.6, respectively), and 4/26 (15 %) with hyperaldosteronism (all had more than double the upper reference limit of plasma aldosterone and urinary aldosterone with hypokalaemia and low renin). This evidence concerns the gene REN and hyperaldosteronism.