In Huntington’s disease, polyglutamine-expanded huntingtin (htt) protein accumulates within intranuclear inclusion bodies or neurites6 and in amyotrophic lateral sclerosis, motor neurons develop protein-rich inclusions containing superoxide dismutase 1, TAR DNA-binding protein 43 or the RNA-binding protein fused-in-sarcoma in their cell bodies and axons7, 8, 9, 10. The gene discussed is HTT; the disease is amyotrophic lateral sclerosis.