At 1 h post-injection, both non-invasive in vivo fluorescence imaging and ex vivo imaging data reveal that besides tumour, intense fluorescence signals are also observed in normal organs such as liver, intestine, and kidney (Supplementary Fig. S15), suggesting that pure DBT fails to selectively image LAPTM4B protein-expressed tumour in vivo. The gene discussed is LAPTM4B; the disease is neoplasm.