PTEN and posterior cortical atrophy: PI3K-C2β was highly expressed in PC3 and LNCaP cell lines, both lacking the tumour suppressor phosphatase and tensin homolog (PTEN), the phosphatase responsible for dephosphorylation of PtdIns(3,4,5)P3, compared to the PTEN expressing PCa cell line DU145 and to PNT2 cells (Fig. 1a).