Many variants of T2DM-related loci had been identified associated with the response of these two drugs in the previous studies, including PSMD6, KCNJ11, ABCA1, SLC30A8, UCP2, KCNQ1, PAX4 and NOS1AP5, 6, 7, 8, 9, 10, 11, 12. This evidence concerns the gene KCNQ1 and type 2 diabetes mellitus.