CBR1 and dementia: Whole temporal lobe proteome displayed increased levels of Gln deamidation in AD + CVD subjects relative to age-matched controls (3.90 % female dementia, 3.87 % male dementia, 3.52 % age-matched controls; chi square 27.698 with one degree of freedom, p-value <0.001) and in female patients we detected increased levels of the enzyme carbonyl reductase 1 (NADPH1) compared with either male patients or controls (iTRAQ ratio female/controls 2.09 ± 0.13; p-value <0.001; gender ratio female/male 2.36).