MBP and proteostasis deficiencies: Deamidation of Gln residues favors the proteolysis of dysfunctional proteins via the ubiquitin proteasome system [52], but Gln deamidation of brain proteins including MBP is also strongly associated with proteinopathy [51, 53, 54] which may resist the degradation of dMBP by the ubiquitin proteasome system.