In-line with predictions, our functional proteomics study confirmed that MBP was hyper-citrullinated in women with dementia, but we also observed an unexpected impairment of dMBP degradation, which was associated with reduced cathepsin D expression and increased MBP deamidation at Gln residues (particularly in the degenerative epitope QDENPVV) [15, 41, 42]. Here, CTSD is linked to dementia.