GLUL and dementia: Since NADPH1 can promote deamidation of Gln residues [48], and we detected a reduction in glutamine synthetase (GS) levels in women with dementia (iTRAQ ratio female/controls 0.5 ± 0.09; p-value 0.002; gender ratio female/male 0.45), these data could explain the impaired glutamine-glutamate metabolism identified in the temporal lobe of female dementia patients.