For the interaction between SH2B3 and COL4A1, the Odds Ratio for CAD was highest for subjects with both the SH2B3 AA genotype and the COL4A1 GG genotype (Table 5; Cochran-Mantel-Haenszel test p value = 0.00047). The gene discussed is COL4A1; the disease is coronary artery disorder.