CXCL8 and dengue disease: We found two kinetic patterns of inflammatory mediator production in dengue patients namely: i) analytes that were elevated in patients with DOF 1–3 but showed a decline thereafter in patients with DOF 4–6 and 7–10 (IFN-α, IFN-γ, IL-7, IL-12p70, MCP-1) (S3A, S3B, S3D, S3H and S3J Fig); ii) analytes that were low in early phases of infection but showed a significant increase at later DOF (IL-6, IL-8, IL-10, IL-12p40, IP-10 and VEGF) (S3C, S3E–S3G and S3I Fig and S3M Fig).