IL6 and Infertility: Previously, we have shown that ROS such as O2•-, H2O2, •OH, and ONOO-, as well as, IL-6, generated in the process of oxidative stress, not only regulates the inflammatory setting and contributions in keeping of chronic inflammatory state but also directly or indirectly affects the metaphase-II oocyte spindle and thus chromosomal alignment and significantly contributes to infertility [4, 5, 46, 51].