BRCA associated protein-1 (BAP1) is a 90kDa ubiquitous nuclear carboxy-terminal hydrolase, the gene for which is located on chromosome 3p21.1.[8] BAP1 has recently been reported to have a tumour suppressor role by way of transcription regulation, chromatin modification, and DNA damage response [9], and the BAP1 gene has been shown to conform to Knudson’s classic two-hit model, whereby biallelic inactivation leads to tumorigenesis with or without germline mutation [8]. This evidence concerns the gene BAP1 and neoplasm.