The single nucleotide polymorphism at codon 64(CCR2-64I, rs1799864) of CCR2 gene that encodesisoleucine (ATC) instead of valine (GTC) has been widely studied, and there are reports ofassociation between this polymorphism and the protective effect in the progression ofinflammatory diseases such as multiple sclerosis (Miyagishiet al. 2003), carotid atherosclerosis (Nyquist etal. Here, CCR2 is linked to carotid atherosclerosis.