CC2D2A and ciliopathy: Furthermore, TMEM-218 can be positioned genetically and hierarchically within the MKS module, likely as a peripheral component, similar to MKS-3 (Tmem67), JBTS-14 (Tmem237), and MKS-6 (Cc2d2a), which are all ciliopathy-associated (Figs 1D, 2D and 7).