In the case of mesothelioma with low ASS1 expression, patients have been treated with pegylated arginine deiminase (ADI-PEG20), either alone (ADAM - https://goo.gl/hSNkI7)) or together with chemotherapy (TRAP - http://goo.gl/tiwzGO), to deprive the tumor of arginine; results from these trials are pending. Here, ASS1 is linked to mesothelioma.