G6PD and hyperinsulinemic hypoglycemia, familial, 4: In human, it had been observed that only a few of G6PD deficient-individuals have hemolytic episode in response to fava beans though favism is associated with class II(1%-10% of normal) and III(10%-50% of normal) of G6PD deficiency, suggesting that the deficiency is a necessary but not sufficient cause of hemolysis [1–2,5].