G6PD and hepatocellular carcinoma: It had been reported that the elevated level of cysteine is related to depletion of glutathione metabolism and oxidative stress induced by diamide in G6PD-deficient hepatoma cells [34].The elevation of cysteine and taurine may reflect the dysregulation of GSH metabolism in G6PDx-FB mice in response to fava bean-induced oxidative stress (Fig 8).