There were 9298person-days of follow-up and the overall incidence rate for central nervous system signs was 2.37 per 100 person-days.Overall, after reviewing the files, 718 were probable dengue fever cases and 887 were biologically confirmed dengue either by NS1 (N = 742) and/or dengue-specific IgM seroconversion (N = 310). This evidence concerns the gene CD40LG and dengue disease.