This isRNA induced IFN-α and to a lesser extent proinflammatory cytokine interleukin-6 (IL-6) production in murine blood serum, efficiently reduced the metastases area in different murine organs and slightly inhibited tumor growth in a hepatocellular carcinoma G-29/CBA/LacSto murine model [24]. The gene discussed is IL6; the disease is hepatocellular carcinoma.