The TLT adaptor molecule TNF-receptor associated factor 6 (TRAF6) seems to play a pivotal role in maintaining intestinal homeostasis since Traf6−/− mice fail to maintain intestinal homeostasis mediated by a reduction of Tregs and an increase of T-helper 2 (Th2) cells, finally resulting in a microbiota composition-dependent induction of colonic inflammation [55]. This evidence concerns the gene TRAF6 and colitis.