Thus, we evaluated real-time mRNA expression of PI3K isoforms: PI3K classes I, II, and III; Akt isoforms: Akt1 and Akt2; and mTOR isoforms: mTORC1 and mTORC2, together with the expression of eEF1A1 and eEF1A2 mRNAs, using an MPP+-induced SH-SY5Y cellular model of PD. This evidence concerns the gene AKT1 and Parkinson disease.